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KMID : 0616120170480020155
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Korean Journal of Pharmacognosy
2017 Volume.48 No. 2 p.155 ~ p.159
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Inhibitory Effects of the Roots of Cudrania tricuspidata Bureau on Osteoclast Differentiation
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Kim Yu-Gyeong
Jeong Gil-Saeng
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Abstract
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Cudrania tricuspidata Bureau (Moraceae) is a traditional oriental medicine that has been widely used as anti-oxidant, anti-inflammatory and immunomodulatory in Korea. This study was performed that the 70% ethanol extract of the roots of C. tricuspidata (CTE) suppressed receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis, actin ring formation in RAW 264.7 cell lines. CTE significantly inhibited the JNK/mitogen-activated protein kinase (MAPK) signaling pathway without affecting ERK and p38 signaling in RANKL-stimulated RAW 264.7 cells. Also, CTE inhibited RANKL-induced expression of c-Fos, an upstream activator of NFATc1. Consequently, CTE suppresses osteoclast differentiation by inhibiting RANKL induced MAPK signaling pathways and disrupts the actin rings in mature osteoclasts. Thus, CTE can be used for the development of osteoporosis treatment drug with a natural material.
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KEYWORD
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Cudrania tricuspidata Bureau, Osteoclastogenesis, RANKL, MAPK, c-Fos, NFATc1
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